In the hemolytic disease of the newborn the mother has Rh- blood. This mother when generating her first Rh+ child makes contact, possibly during delivery, with Rh+ red blood cells of the child and her immune system triggers the primary immune response against the Rh factor.
In the next gestation in which the fetus is Rh+ the mother will already have much more anti-Rh antibodies in her circulation; these antibodies cross the placental barrier and gain the fetal circulation causing fetal hemolysis (destruction of the red blood cells of the fetus).
How does the immune process that causes the hemolytic disease of the newborn take place?
Answers
Mr. Santosh
In the next gestation in which the fetus is Rh+ the mother will already have much more anti-Rh antibodies in her circulation; these antibodies cross the placental barrier and gain the fetal circulation causing fetal hemolysis (destruction of the red blood cells of the fetus).