Human insulin when initially synthesised in human body consists of three peptide chains- A, B and C. The C-peptide is an extra stretch of amino acids joining the A and B-chains. This is called proinsulin or prohormone. It undergoes processing or splicing to release the functional mature insulin that can carry out its normal functions. During processing, the C-peptide is removed. Only A and B-chains contribute to form the functional insulin.
Human insulin when synthesised in the body needs to be processed before it can act. Explain giving reasons.
Answers
Purvesh Kale
Human insulin when initially synthesised in human body consists of three peptide chains- A, B and C. The C-peptide is an extra stretch of amino acids joining the A and B-chains. This is called proinsulin or prohormone. It undergoes processing or splicing to release the functional mature insulin that can carry out its normal functions. During processing, the C-peptide is removed. Only A and B-chains contribute to form the functional insulin.